Search results for "Selenium deficiency"

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Role of endoscopic ultrasonography in the evaluation of high risk pancreatic cystic lesions: Ten year single center experience

2012

s / Pancreatology 12 (2012) 502–597 530 selenium content in second group was increased up to 96,5 3,29 mg/l (p <0,001). Conclusions: SS is an effective drug in treatment of selenium deficiency and could be used in initial complex therapy for pain relief in CP.

medicine.medical_specialtyHepatologybusiness.industryEndocrinology Diabetes and MetabolismGastroenterologyPain reliefEndoscopic ultrasonographySingle Centermedicine.diseaseSurgeryCystic lesionSelenium deficiencymedicinebusinessPancreatology
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Selenoprotein synthesis and side-effects of statins.

2004

Statins are possibly the most effective drugs for the prevention and treatment of hypercholesterolaemia and coronary heart disease. They are generally well tolerated, however, they do cause some unusual side-effects with potentially severe consequences, most prominently myopathy or rhabdomyolysis and polyneuropathy. We noted that the pattern of side-effects associated with statins resembles the pathology of selenium deficiency, and postulated that the mechanism lay in a well established, but often overlooked, biochemical pathway--the isopentenylation of selenocysteine-tRNA([Ser]Sec). A negative effect of statins on selenoprotein synthesis does seem to explain many of the enigmatic effects a…

medicine.medical_specialtyHypercholesterolemiaCoronary DiseaseBioinformaticsModels BiologicalRhabdomyolysisPolyneuropathiesSeleniumMuscular DiseasesSelenium deficiencyInternal medicinemedicineHumanscardiovascular diseasesSelenium metabolismMyopathySelenoproteinschemistry.chemical_classificationbusiness.industrynutritional and metabolic diseasesProteinsGeneral Medicinemedicine.diseaseCoronary heart diseaseEndocrinologychemistryProteins metabolismProtein Biosynthesislipids (amino acids peptides and proteins)Selenoproteinmedicine.symptomHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessRhabdomyolysisPolyneuropathyLancet (London, England)
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